This study focuses on the formulation and optimization of cubosomes encapsulating gingerol, a bioactive compound isolated from the rhizome of Zingiber officinale (ginger). Cubosomes, nano-structured lipid carriers, were designed to enhance the bioavailability and therapeutic efficacy of gingerol, which is known for its antiinflammatory and antioxidant properties. The research employed various techniques for analyzing the entrapment efficiency, cubosome size, shape and morphology. The Cubosomal gel characterization was done by visual and physical parameters including homogeneity, viscosity, pH, spreadability. In vitro drug release parameters were also assessed. The optimized cubosomes exhibited enhanced encapsulation efficiency and controlled release, indicating their potential as an effective delivery system for gingerol. The findings underscore the promise of cubosome-based delivery in enhancing the medicinal benefits of herbal compounds