Multidrug Resistance Tuberculosis (MDR-TB) is type of tuberculosis caused bacteria resistant to 2 lines of anti-TB drugs First namely isoniazid and rifampicin . Ratio level the incidence of loss to follow-up TB was 12.19% . A total of 37 patients is a loss to follow-up with level incidence 11.26 per 1000 person-months of observation (PMO) . Lack of factors support family , lack of fulfillment nutrition , distance to facility health in a way significant influential to occurrence of loss to follow-up 18 . Indonesia bears it TBC RO load as one disease highest in the world. His height number separated treatment around (20-30%) and high number deaths (15-20%) impact the numbers success ongoing RO TB treatment ranges from 20-50% in One decade . One of factor can background matter the like provision guide RO TB treatment without injection with longer duration short ( guide treatment period short oral) 8 . Objectivestudy This is For know determinant separated treatment for MDR-TB patients . Study This nature analytic observational with design studies case control with approach retrospective . Research sample This consisting of 128 people from group case is MDR-TB dropped out patients treatment as many as 32 people, and controls is subject MDRTB sufferers Which Still do treatment , and have finished treatment as many as 96 people. Risk factors for dropping out of treatment that is Motivation (OR 5) CI 95% (1.96-12-87), side effects (OR 7.05) CI 95% (0.79-3.11), the role of the PMO (OR 5.63) CI 95% (0.52-2.93), treatment time (OR3.23) CI 95% (1.14-10.40), herbal medicine (OR 21.97) CI (1.67-4.08) . Regression analysis Logistics show that herbal treatment is the main determinant of dropping out of treatment in MDRTB sufferers.