The primary goal of this work was to create and assess an Emulgel that contains an Econazole Nitrate nanostructured lipid carrier (NLC) for topical administration. An imidazole derivative substance called econazole nitrate (ECN) is mostly used to treat surface infections. Fungal infections are treated by topical application of econazole nitrate. Using a high-pressure homogenization process, for solid lipid stearic acid and liquid lipid oleic acid is used and it combined with surfactants (Span 80 and Tween 80) to create econazole nitrate NLC. The zeta potential, SEM, and particle size of this nanostructured lipid carrier containing econazole nitrate were assessed. Lipid nanoparticles were mixed with emulgel to be applied topically, and their antifungal, in vitro drug release, pH, drug content, viscosity and stability tests were assessed. Up to three months, the stability testing revealed no appreciable changes in the formulation. Ultimately, it can be said that one of the more promising methods for regulating the release of the medication is the Econazole Nitrate emulgel loaded with NLC topical medication administration for more thorough and successful care.