Phospholipid-containing mixed micelles are better at delivering drugs because they can better bind, load, and penetrate drugs through lymphatic drug absorption pathways, increasing the drug's systemic bioavailability. Hence the drug like docetaxel can be incorporated and deliver using phospholipid based polymeric mixed micelles (Ph PmM). Present work represents the enhanced solubility and bioavailability of poorly aqueous soluble docetaxel. The Box-Behnken design was used for optimization of formulation and processing parameters like concentration of phospholipid, surfactant and drug. Prepared docetaxel loaded Ph-PmM were characterized for physicochemical and functional properties. The particle size of the Ph mM was found to be 180 nm. The Ph-PmM were found to be thermodynamically stable which was confirmed by negative zeta potential value of about -40 mV. The drug was compatible with the other excipients, confirmation was done by DSC and FTIR. The drug released study of the drug loaded Ph-mM and pure drug showed that the sustained release of drug from the Ph-PmM. The solubility of drug was also increased due to Ph complex formation. Hence the Ph-mM has the potential to improve the bioavailability of docetaxel.