In the article Malibu against weeds in the Cotton field in the conditions of typical oxen soils of the Tashkent region, 50 W.d.g. and Gambit CK, 500 g / l.e.c. data on the effectiveness of the use of herbicides separately and in front-to-back are presented. Gambit CK, 500 g/l.e.c. It lost 86.2-87.7% of annual weeds per year when applied in the 1.5 l/ga norm. The Malibu 50 herbicide lost 85.7-88.0% of perennial weeds in the fall when applied in a 2.0 l/ha norm., Malibu 50 in the fall and Gambit CK, 500 herbicide lost 90.0-93.5% of annual weeds, 88.5-91.8% of perennial weeds, when applied precast with Cotton planting in the 1.5 l/ga norm.