Volume 6 | Issue -14
Volume 6 | Issue -14
Volume 6 | Issue -14
Volume 6 | Issue -14
Volume 6 | Issue -14
Introduction-Theoralcavityisthesitewherefoodisreceived and therefore an area of body where contact with exogenous materialsis particularly intense. In response to exogenous materials protective mechanisms are an increased capacity for epithelial regeneration, and increased keratinization. These epithelial changes are reactive and reversible, but with progressive loss of normal control mechanism they leadtoprecancerousstatesandoralcarcinoma.Morethan90%ofalloral cancers are squamous cell carcinoma (SCC). The most important risk factors for oral SCC are use of tobacco or betel quid which is also responsible for oral submucousfibrosis(OSMF). There has been increased incidence of concomitant association of OSCC & OSMF in recent times.Thus the aim of this study is to evaluate the effect of individual variables on disease free survival in patients having SCC alongwith OSMF. MaterialandMethods-Aretrospectiveobservationalstudywascarriedout in whichrecords of patients were retrieved from 2011 to 2014. A total of 78 patients having OSCC with OSMF were taken up for the study. Patients present clinical information was obtained through telephone calls.Patientswereevaluatedondemographic,clinicalandpathological fronts and its effect on disease free survival was studied. Results- Out of 78 patients overall 3 year disease free survival was foundtobe84.62%.Patientswithnegativemarginshadsubstantiallylow recurrence as compared to those who had positive surgical margins. Regardstopresentstudyrecurrencewaspresentin12patientswhichwas foundtobethesolefactorhavingprofoundimpactonsurvival.Restall variables did not have impact on disease free survival. Conclusion- Good survival rate can be obtained with primary surgical treatment.Preoperativeassessmentoffactorssuchasstageoflesion, cervical lymph node metastasis, extracapsular spread, staging of OSCC, grading of OSMFplay a crucial role in predicting recurrence post- operatively. Thus, to improve survival rates, recurrence has to be minimized which in turn is controlled by above factors