Objective: This study aims to evaluate and compare the Effect of exposure of Etidronic acid, Sodium Hypochlorite and E.D.T.A on the bond strength of calcium silicate based cements– An in vitro study Materials and method: 180 sections (2 mm thick) of coronal root dentin were obtained from roots of 180 extracted teeth; the canals were enlarged to a standardized perforation cavity diameter of 1.4 mm. Sections were randomly divided into 2 groups (n = 90 per group), and cavities were filled with ProRoot mineral trioxide aggregate (MTA) and Biodentine™ according to the manufacturers' instructions. . Each group was further divided into subgroups exposed to different root canal irrigants: 5.25% Sodium Hypochlorite (NaOCl) alone, NaOCl with 17% EDTA, and NaOCl with 18% Etidronic acid (HEBP). The specimens were analyzed after 1 day and 21 days for Push-out bond strength. The values were measured using a universal testing machine under a compressive load at a speed of 1 mm/min. Data were analyzed using one way analysis of variance test at a significance level of p < 0.05.