This study evaluated the effect of aquous extract of sesamum indicum seeds (A.E.S) against mercuric chloride (HgCl2) induced toxicity on females’ reproductive system in rat. Forty female Wistar adult rats weighing (130-160 gr), divided into four groups (10 rats each): control group(C), intoxicated group (Hg), treated control group (C+A.E.S),intoxicated treated group(Hg+ A.E.S) .Females adults rats were given HgCl2 (2 mg/kg body weight) in drinking water for 45 Days .After the period of intoxication the rats are treated daily with (400 mg/kg body weight) of Sesamum indicum seeds extract given orally by gavage for (21) days. After the treatment period, each group subdivided into two groups (five rats each). One group of rats mated with unexposed males to study reproduction parameters, other group was sacrificed after treatment period; the Ovary and Uterus were taken for histopathology studies and blood samples were transferred to thel aboratory for biochemical analysis. Malondialdehyde (MDA), glycose levels and Serum activities of alkaline phosphatise (ALP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), increased and serum levels of total protein, total cholesterol decreased in the intoxicated group (Hg) compared with control group(T). Whereas Body weight, ovaries and uterus weights, catalase, superoxide dismutase (SOD), glutathione peroxidise (GPX) activities, estrogen and progesterone levels were decreased in the intoxicated rats. There was no change in fertility index between groups. While, result of the number of newborns for the Hg group showed no significant decrease as compared with the others Group. Moreover, the percentage of weanlings from the intoxicated group showed a significant increase as compared with the control group. Also; HgCl2 exposure resulted in histopathological changes in the ovaries. Our conclusion pointed out that Sesame seeds have an protective effect ondamages caused by Hgcl2 and levels of some hormones.