Polycystic ovarian syndrome is the major cause of an ovulatary infertility, which is mainly because of insulin resistance. Myoinositol, a nutrient belonging to vitamin B family has shown to improve hormone profile and metabolic disorders in patients with PCOS by amelioration of pre-existing insulin resistance. Vitamin D also has a positive effect on folliculogenesis. This study analyses the effect of using Myoinositol and Vitamin D3with Clomiphene Citrate on the ovulation in infertile women with PCOS. Aim: To evaluate the effectiveness of using Myoinositol and vitamin D3 with Clomiphene Citrate for ovulation induction in infertile women with PCOS. Methodology: Inpatients with PCOS and infertility, total of 94 patients were enrolled and the first group of patients received Myoinositol and vitamin D3 with Clomiphene Citrate and the second group of patients received Clomiphene Citrate alone. Results: Ovulation rate in group 1 was 32.25% and group 2 was 31. 5%. Satisfactory endometrial response rate was 25.9% in group 1 and 22.4% in group 2. Overall follicular rupture rate was 22.7% in group 1 and 25.5% in group 2. Conclusion: The addition of Myoinositol and Vitamin D3 with Clomiphene citrate in PCOS women improves the ovulation and pregnancy rates. The addition of Myoinositol and Vitamin D3 does not have any undue side effects.