Purpose of Review: Vagus nerve stimulation (VNS) has introduced as a potential therapeutic modality for many neurological diseases. In recent years, there is an increasing interest in VNS for treating ischemic stroke. This review aimed to illustrate and discusses the evidence supporting VNS as a treatment option for ischemic stroke. Methods: We searched Science Direct, Google Scholar, and PubMed for, ischemic Stroke, non- invasive vagus nerve stimulation, stroke recovery and cognitive function in stroke. The authors also reviewed references from pertinent literature, however only the most recent or comprehensive studies from December 2011 to February 2024 were reviewed. Documents in languages other than English were disqualified due to lack of translation-related sources. Papers such as unpublished manuscripts, oral presentations, conference abstracts, and dissertations that were not part of larger scientific studies were excluded.