cis-Diamminedichloroplatinum (II),generally brandedascisplatin (CDDP), is a first-line chemotherapeutic agent that has several uses in a wide choice of cancer conditions. The comprehensive prescription of cisplatin is concomitant with some less- known adverse effects such as genotoxicity, hepatotoxicity, nephrotoxicity and sperm toxicity etc. Cisplatin generates enormous quantity of free radicals which causesoxidative stress by different mechanism. Sperm and chromosome are repeatedly dividing cells, which when damage at their level, will directly imitate in the arrangement that can be identified by micronucleus and sperm structure study .The present investigation explores the probable potential of Ventilago denticulata bark extract against cisplatin inducing genotoxicity in bone marrow and sperm toxicity in testies of albino rats