Purpose: To investigate the effect of interactive training on muscle strength and motor proficiency in children with hemiparesis. Methods: Thirty children of both sexes with hemiparesis included in this study, aged 8 to 10 years. They were randomized into control and study groups. Both groups received a specially designed physical rehabilitation program. Additionally, the study group participated in Wii Fit virtual reality-based program. Hip and knee extensors' strength were measured using a Lafayette hand-held dynamometer. Bilateral coordination, strength, running speed, and agility were evaluated using the Bruininks-Oseretsky Test of Motor Proficiency, (BOT-2) 2nd edition before and after the treatment program. Results: Children in both groups showed significant improvements in their post-treatment results across all measured outcomes compared to their pretreatment results. When comparing the post-treatment mean values between the groups, the study group exhibited significantly greater improvement than the control group ((P<0.05). Conclusion: Adding interactive training to the designed physical therapy program provide a significant effect on muscle strength and motor proficiency in children with hemiparesis.