Background: Preeclampsia poses severe maternal and perinatal risks. Although folic acid may reduce homocysteine levels, its effectiveness in lowering preeclampsia risk remains debated and inconclusive. This systematic review and meta-analysis aim to evaluate the efficacy, effectiveness, and safety of folate supplementation for preeclampsia based on literatures of the last 10 years. Method: A systematic review and meta-analysis were conducted according to PRISMA 2020 guidelines using the PICO framework. Rigorous screening, data extraction, risk of bias assessment, and statistical analysis were performed to evaluate the effectiveness, efficacy, and safety of folate supplementation for preeclampsia. Results: A total of 89 articles were retrieved from online databases (PubMed, SagePub, Nature and Cochrane). After three rounds of screening, five articles directly relevant to the meta-analysis were selected for full-text reading and analysis. The results showed that the effectiveness of folate supplementation for preeclampsia is not statistically significant with overall size effects of RR = 0.81 (95% CI: 0.59, 1.13) Conclusion: The meta-analysis indicates that folic acid supplementation alone does not significantly reduce pre-eclampsia risk.