Closed chain and neuromuscular training both are believed to enhance the joint stability, proprioception, coordination, balance and agility. This research work revolves around the need to compared the effects of closed chain exercises and neuromuscular training with the aim to identify the optimal rehabilitation approaches for football players with chronic ankle sprain. Objective of the study was to determine the effects of closed chain exercises versus neuromuscular training on pain and range of motion in football players with chronic ankle sprain. The study design was Randomized Clinical Trial. Total 34 subjects of both male and female gender with age 18-35 participated. Non Probability Convenient Sampling Technique was used. Conducted in Pakistan Sports Board (PSB) Lahore and completed within 10 months. Closed chain and neuromuscular training groups each 17 participants given exercise plans for 4 weeks. Assessment was done by Pain (NPRS) and range of Motion (Goniometer). The data was analyzed using SPSS, 25. Statistical significance was set P= 0.05.