the aim of this study was to evaluate the effect of splint use on the accuracy of dental implant surgery. Method: In present systematic review and meta-analysis, information about splint use on the accuracy of dental implant surgery in all articles published until the end of July 2023 through searching in databases PubMed, Scopus, Science Direct, ISI, Web of Knowledge, Elsevier, Wiley, and Embase and Google Scholar search engine were extracted using keywords and their combinations by two trained researchers independently. Data analysis was done using the fixed effects model in meta-analysis, by STATA (version 17); P-value less than 0.05 was considered significant. Result: A total of nine studies were included in the meta-analysis process. the mean of horizontal coronal deviation for tooth and mucosa was 0.59mm (MD: 95% CI, 0.24mm to 0.93mm; I2=0; p=0.47) and 0.84mm (MD: 95% CI, 0.47mm to 1.20mm; I2=2.08; p=0.38), respectively. the mean of angular deviation for tooth and mucosa was 0.95mm (MD: 95% CI, 0.75mm to 1.14mm; I2=42.77; p=0.14) and 3.38mm (MD: 95% CI, 1.51mm to 5.25mm), respectively. Conclusion: Based on the present meta-analysis, no statistically significant difference was observed in any of horizontal coronal deviation, horizontal apical deviation, or vertical deviation, except angular deviation, compared to tooth-supported splints and mucosa-supported splints