The purpose of this study was evaluate the overall survival rate of salvage surgery in recurrent head and neck squamous cell carcinoma. Method: Databases of PubMed, Scopus, Web of Science, EBSCO, ISI Web of knowledge and Embase were searched for systematic literature until March 2023. Data analysis was performed using STATA/MP V17 software. 95% confidence interval for effect size with fixed effect model and Inverse-variance method were calculated. Result: In the initial review, duplicate studies were eliminated and abstracts of 1340 studies were reviewed, the full text of 103 studies was reviewed by two authors, finally, six studies were selected. Hazard ratio was 0.23 (HR, 0.23 95% CI 0.06, 0.41; p<0.05). Overall survival after five years was 0.40 (OS, 0.40 95% CI 0.18, 0.63; p<0.05). Conclusion: Based on the current meta-analysis, the survival benefits for patients with HNSCC who underwent salvage surgery were more than patients receiving other treatment methods such as radiation therapy and chemotherapy