Aim: This study assesses the impact of complete denture rehabilitation on oral health-related quality of life (OHRQoL) in completely edentate individuals from North Gujarat, India. Purpose of Study: The psychological traits of an edentulous patient may impact their oral health-related quality of life (OHRQoL) but are insufficiently considered while rendering treatments. The evaluation of patient’s perceptions regarding the interventions they receive has been profoundly influenced by the assessment of oral health-related parameters and their impact on quality of life (QoL). Materials and Method: An evaluation was conducted on 66 edentulous individuals, aged 50 to 70, who were treated by postgraduate students at Narsinhbhai Patel Dental College and Hospital. A specialized questionnaire, the Oral Health Impact Profile for edentate patients (OHIP-EDENT), was employed to collect data on oral health-related quality of life (OHRQoL). In addition, inquiries regarding the patient’s satisfaction with their complete prosthesis were recorded. The patients underwent assessments at baseline, one month, and six months following the placement of new complete dentures. Result: Statistically significant improvements in OHRQoL were noted at both one and six months following the insertion of complete dentures. The degrees of dysfunction, distress, and disability related with oral issues at baseline and one month later showed no statistically significant variation. All parameters of the OHIP-EDENT demonstrated substantial improvements following rehabilitation with new complete dentures. Furthermore, patient satisfaction experienced a substantial rise following complete denture insertion. Conclusion: The study prove the effectiveness of complete denture therapy in improving overall health-related quality of life (OHRQoL) and highlight the significance of long-term follow-up in determining the complete effects of dental therapies. As a consequence, conventional complete dentures remain a feasible choice for rehabilitating edentulous individuals.