This cross-sectional study aimed to assess the knowledge and decision-making processes of dental students, interns, and general practitioners regarding tooth extraction methods. Methods: A questionnaire was distributed online to 113 participants, including fifth and sixth-year dental students, interns, and general practitioners at King Abdulaziz University Hospital. The questionnaire evaluated participants' awareness of numerous factors influencing the decision for simple versus surgical tooth extraction, including tooth-related, prosthodontic, periodontic, and endodontic factors. Results: Showed that while the majority demonstrated good decision-making based on their knowledge and experience, variations existed, particularly among dental students, due to differing levels of understanding. Despite some discrepancies, participants agreed on factors contributing to simple tooth extraction. Conclusion: The study highlights the importance of continuous education and training to enhance practitioners' competency in tooth extraction decision-making, improving patient care and treatment outcomes. Limitations included the small sample size of general dentists and the focus on a single institution, suggesting the need for larger-scale studies for generalizability.