Oxidative stress in diabetes can lead to difficulties due to the overproduction of precursors to reactive oxygen radicals and the impaired efficacy of inhibitory scavenger systems. Diabetes mellitus can cause persistent consequences, including senile diabetic cataracts. This study examined NIDDM (Type-2) patients with or without cataracts. Diabetics experience higher levels of oxidative stress, as measured by malondialdehyde (MDA), compared to normal individuals (181.04 nmol/l). Diabetics with cataracts have significantly higher levels of oxidative stress (399.12nmol/l) than diabetics without complications. The present study attempted to assess serum MDA levels as a measure of free.