Objective: Cordyline fruticosa plant part has various ethno-pharmacological properties against various body ailments including pain, sore throat, bleeding haemorrhoids, fever, smallpox, inflammation of digestive tract and rheumatoid arthritis. Methods: In-vivo anticancer investigation of Cordyline fruticosa leaf extract was conducted through various established methods including inhibition of cell growth, average tumor weight and mean survival time, apoptosis by DAPI staining, hematological parameters and brine shrimp lethality bioassay. Anticancer properties of Cordyline fruticosa leaf extract were investigated using Ehrlich's ascites carcinoma cell-bearing Swiss albino mice.