Introduction: Impaction surgeries for mandibular third molars often result in postoperative pain, swelling, and trismus due to the inflammatory response. Managing these symptoms effectively is crucial for patient comfort and recovery. Corticosteroids, particularly dexamethasone, are known for their potent anti-inflammatory effects, which they achieve by inhibiting the phospholipase A2 enzyme in the arachidonic acid pathway. This study aims to evaluate the effectiveness of post- operative dexamethasone administration via submucosal and intravenous routes in reducing postoperative discomfort. By comparing these two administration methods, we seek to determine the most effective approach for minimizing pain, swelling, and trismus following mandibular third molar extractions.