This experimental animal study evaluates the protective effects of Cocos nucifera L. sprout on cisplatin -induced nephrotoxic rats over 14 days. Wistar rats were randomly divided into six groups (n=6). Group I rats received 0.5 % CMC, while Group II rats were treated daily 0.5 % CMC (p.o.) with cisplatin 5 mg/kg (i.p) on 11th day. Group III were administered daily oral doses of 5 mg/kg cystone (p.o.) with cisplatin 5 mg/kg (i.p) on 11th day. Groups IV, V, and VI were administered daily oral doses of 100 mg/kg, 150 mg/kg, and 200 mg/kg HAECN, respectively, with cisplatin administered on the 11th day. On the 15th day, blood samples were collected for serum creatinine, BUN, protein, sodium & potassium analysis. The kidneys were harvested for histopathological examination. Results indicated that group I (0.5% CMC-treated rats) showed a normal gain in body weight compared to the DC group. In group II, there were significant increases in serum creatinine and BUN, sodium, along with decreases in body weight, protein & potassium levels as well as acute tubular nephritis. These effects were significantly reversed in cystone- and HAECN-treated rats in a dose-dependent manner, suggesting that HAECN has nephroprotective effects due to its antioxidant properties.