Diabetic Foot Ulcer is a chronic disease associated with Diabetes Mellitus or hyperglycemia. Globally around 35% of Diabetic patient are at a risk of developing DFU, out of which 50% are at high risk of reoccurrence of the disease. It is the most prominent reason for amputation of lower limb, high rate of hospitalization and mortality in diabetic patient. It is increasing burden on health economy and lifestyle of diabetic person. The current research focuses on effect of curry leaves (Murraya koenigii), a widely used plant in Indian culinary on Streptozotocin induced diabetic foot ulcer in Albino Wistar Rats. Ethanolic and Hydroalcoholic extract of curry leaves are prepared and given orally for 21 days of study period. The histopathological and other laboratory analysis evidence shows that the hydroalcoholic extract of curry leaf enhance diabetic foot ulcer healing. Hence the study concluded that curry leaves has therapeutic potential to be used in the treatment of Diabetic Foot Ulcer.