In this current research work two plants collected, extracted and evaluate their antidiabetic activity. We conducted a study to examine the preventative impact of the hydroalcoholic extracts of Adenium obesum and Gazania rigens on insulin resistance caused by dexamethasone in experimental animals. The albino wistar rats were organized into seven groups. One group included of healthy animals, while the remaining six groups were utilized for generating diabetes. Following an 18-hour fasting period, the animals with diabetes were given the subsequent treatment. After a 6-day duration of administering dexamethasone, the animals with diabetes were later administered the same treatment. The standard drugs Glibenclamide (5 mg/kg) and Pioglitazone (2mg/kg) and test samples Adenium obesum and Gazania rigens, with a dose of 400 mg/kg body weight and combination of both extracts (400 mg/kg body weight) were administered orally in a single dose over a 15-day period via a gastric tube. The combination of hydroalcoholic extracts from Adenium obesum and Gazania rigens demonstrated a protective effect against insulin resistance induced by dexamethasone.