The aim of this study was to assess the anti-inflammatory potential of intracanal medicaments by comparing the effectiveness of zinc oxide nanoparticles (ZnO NPs) mixed with herbal extracts to a conventional intracanal medicament. Herbal extracts from Azadirachta indica and Solanum xanthacarpum were used to synthesize ZnO NPs. Antiinflammatory activity was evaluated through protein denaturation and membrane stabilization assays. The results indicate that ZnO NPs combined with herbal extracts exhibit superior anti-inflammatory effects compared to the standard intracanal medicament. Further clinical studies are recommended to validate these findings.