The success of implants’ osseointegration in diabetic patients with compromised healing potential, is a major challenge. The study aimed at evaluation of laser biostimulation effect on osseointegration of implant covered by PRF in controlled diabetic patients with compromised healing. Methods: Patients received 22 implants covered with PRF inserted in posterior maxilla or mandible. Implants were divided randomly into 2 groups. Group1: control (no laser irradiation), group2: diode laser. Peri-implant new bone density and secondary stability were assessed using cone-beam computed tomography and Anycheck device respectively. Density was evaluated immediately post implant insertion and after 5 months, while stability was evaluated 5 months post implant insertion. Statistical analysis was executed significance level P ≤ 0.05. RESULTS: Significantly improved density over time was recorded within each group from immediate to 5 months (p≤0.05). Comparing both groups revealed no statistical significance in bone density regarding per-implant buccal, lingual, distal, and mesial surfaces of bone after 5 months (p>0.05). Stability measurements revealed no significance between both groups after 5 months. CONCLUSION: Either applying PRF solely or in conjunction with laser, could be used as effective tools in diabetic patients with compromised healing potential improving osseointegration by time. Laser biostimulation combined with PRF had a modest effect on PRF.