Background: Ethnobotanical practices have long utilized plant-based treatments for managing digestive disorders. Despite their historical significance, scientific validation through experimental research remains limited. Objectives: This study aims to validate traditional plant-based treatments for digestive disorders through rigorous experimental methods. Specifically, it seeks to assess the efficacy and safety of selected plant treatments. Methods: We conducted a randomized controlled trial involving participants with diagnosed digestive disorders. Twelve plant-based treatments were evaluated, with participants assigned to either a treatment or a control group. Dosage, administration, and duration were standardized. Post-treatment symptom scores were compared between groups, and phytochemical analyses were performed to identify active compounds. Results: Significant improvements were observed in the treatment group compared to the control group across several symptoms, including reduced severity of abdominal pain and bloating. Statistical analyses revealed significant differences (p < 0.05) and moderate to large effect sizes (Cohen’s d ranging from 0.90 to 1.30). Phytochemical analysis confirmed the presence of key bioactive compounds in the treatments.