This study looks into the anti-inflammatory properties of pyrazolines, a family of naturally occurring compounds with a variety of organic workouts. Pyrazolines are manufactured green. Utilizing plant extricates as reduction specialists and safe amalgamation procedures that do not hurt the ecosystem, the pyrazolines were produced in a way that minimizes the use of dangerous synthetic compounds and aligns with practical scientific practices. To validate the synthesis and properties of the pyrazolines, various spectroscopic techniques were employed to describe the compounds. The study of in vitro anti-inflammatory activity involved studies that inhibited important inflammatory mediators such as prostaglandins, cytokines, and nitric oxide (NO) in macrophage cell lines. The results showed that these inflammatory go between were significantly and somewhat subtly inhibited by the green-synthesised pyrazolines, significant regions of strength for demonstrating inflammatory qualities. Furthermore, the cytotoxicity tests demonstrated that the mixes were safe for normal cells to concentrate on, highlighting their potential as safe anti-inflammatory experts. When considering the response investment requirement, green solutions such as the microwave strategy and crushing procedure have been determined to be superior to the old technique. 1H NMR, 13C NMR, IR, and mass ghostly investigations have all been used to characterize comp research (2a-I) and (3a-I). There in vitro anti-inflammatory properties were assessed.