Benzofuran is highly significant for further investigation because of its unique pharmacological profile, which includes an anticancer development. Another great option for property showcasing are chalcones, which are the restricted names for a few of natural mixes that belong to the flavonoid class. The material was shown as a specific sequence of chalcones. Recently coordinated and mixed chalcones were tested for their anticancer effects in vitro using prostate cancer cell lines. When determining if an excess of chemicals possess anticancer characteristics, the diphenyltetrazolium bromide test is an invaluable tool. The suggested chalcone compounds were subjected to a cell responsiveness test and their potential was increased after a 24-hour treatment period. Our data shows that the attempted chalcone improves anticancer effects against cell lines, with a p-value less than 0.04.