This ethno-medicine survey explores the rich diversity of medicinal plants in Sagalee, Papum Pare, Arunachal Pradesh, India. Recognizing the historical significance of plant-derived medicines, this study delves into the traditional knowledge of over 500 medicinal plant species within the region. The ethnobotanical investigation aims to understand the distribution of plant uses based on gender, age, and education, shedding light on the integral role these plants play in the cultural and economic fabric of Arunachal Pradesh. The study encompasses 28 ethnic groups, each possessing unique insights into plant utilization for therapeutic purposes, highlighting the cultural importance of traditional medicine. Employing a retro-prospective observational design, the research gathers data through house-to-house interviews from a sample size of 500 individuals over six months. Preliminary results indicate varying patterns of traditional medicinal plant usage, showcasing the dynamic interplay between cultural practices and healthcare systems in the region. Further analysis promises insights into the sustainable integration of medicinal plants within Arunachal Pradesh's socio-economic landscape.