The entire globe was still, no transactions, no circular flow of money, trading stood still, and the list goes on. It was at that time one industry was more curious and actively engaged in the manufacturing and research activity. It takes us to the year 2019, COVID tenure and the industries we are taking is nothing but pharmaceutical industries. The research article focuses on the large capital pharma industries to identify the risk and return and to establish relationships of the same in the selected companies. For the study descriptive statistics was used to analyze the data. With the help of mean, median, standard deviation, skewness and kurtosis risk was identified for the specified trading days for the period of five years from 2019-2023. The result of the study clarifies that the risk and return have a positive relationship where it proves higher the risk higher the return.