Gastric cancer is a significant concern with many unanswered questions, particularly cancer stem cells, the tumour environment, and specific gene expressions. The prognosis for advanced gastric cancer remains poor. Identifying predictive markers for cancer progression and prognosis would help assess clinical outcomes and potential treatment stratification for gastric cancer patients. This study aims to analyse the role of CD44 and CDH-11 in gastric cancer. The study will include 30 gastrectomy specimen reports, and the clinicopathological parameters will be noted. The expressions of CD44 and CDH-11 will be examined in the tumour tissues. The statistical analysis will be performed. Our study found that most gastric carcinoma patients were men aged 61-70. Tumors were mostly poorly differentiated, with intestinal-type adenocarcinoma being the most common. CD44 expression was observed in 80% of patients and was associated with tumour grade and extent. The study found a significant association between CD44 expression and tumour grade (p=0.005). Our study found that 80.0% of CD44-positive cases also showed positive Cadherin 11 expression. Statistical analysis suggested a potential link between the two markers, with a trend towards correlation that requires further investigation. Hence, CD44 could serve as a prognostic indicator for gastric cancer.