To combat resistant bacterial strains, a series of compounds (3a-3e) were synthesized in excellent yield of 91-95%. These analogs were subjected to preliminary screening against various bacterial strains, including Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae, and S. typhimurium to evaluate their effectiveness as antibacterial agents. 3a was the most effective inhibitor with excellent inhibitory effects against E.coli with minimum inhibitory concentration (MIC) values of 500 μg/mL. In silico predictions of physicochemical properties underscored the drug-like qualities of the designed compounds. Additionally, molecular docking poses, LigPlot images, and a binding affinity of -8.5 kcal/mol further reinforced their potential as promising antibacterial agents. Briefly, the reported compound 3a may be the future broad-range antibacterial agent.