Patient safety is the most important factor to consider in the hospital setting. Nurses have the most interactions with patients, thus they will undoubtedly play a role in enhancing patient safety. Various elements will develop during the course of providing services, influencing the improvement of patient safety. These variables can serve as focal points for enhancing and addressing safety culture in management. This study seeks to determine the elements that impact nurses in their endeavors to enhance patient safety. The research was conducted using the PICO method, which involves describing the population as nurses, using patient safety as the intervention (no comparisons), and identifying factors that influence nurses to improve patient safety. Articles or journals were used as the inclusion criteria. National and international publications covering a five-year period (2017-2021) can be downloaded in full text in Indonesian and English, exploring aspects connected to nurses' roles in enhancing patient safety. This literature review found that nurses' knowledge of patient safety incidents, their attitude, their length of service (greater than three years), the encouragement they receive from the room leader and hospital administration, the frequency and quality of their supervision, and the training they receive all contribute to better patient safety. After reviewing the relevant literature, we can say that nurses' abilities to improve patient safety are affected by their knowledge, attitude, length of service, motivation, supervision, and training.