Background: Oral mucositis is characterized by erythema, edema and ulcerations of oral mucosa, an adverse effect of chemotherapy and radiotherapy isa severely debilitating condition. Severe form of oral mucositis leads to worsening of patients' quality of life and limiting compliance with treatment leads to withdrawing. Aim of this study is to assess the factors related with oral mucositis (OM) in patients receiving chemotherapy and radiotherapy in head and neck cancer(HNC). Methodology:Data on 30 patients with oral mucositis and head and neck cancer were gathered. The Multinational Association of Supportive Care in Cancer and the International Society of Oral Oncology (MASCC/ISOO), a research and educational organization published clinical practice guidelines for oral mucositis, served as the basis for the selection of factors.Verified collected data were then imported into SPSS. Bar charts were created in SPSS after each category's individual frequency distributions were evaluated. The Chi-square test and descriptive statistics were used. Results: Factors associated with patient having oral mucositis were predominantly present in male patients18(60%) with Comorbidity like diabetes 21(70%), poor oral hygiene, decreased salivary secretion, reduced weight ,higher dosage treatment in shorter period 24(80%) respectively, low hematological parameters 27 (90%) , more than 5 cycles of chemotherapy 21 (70%) and majority of patients received cisplatin infusion 18(60%). Majority of male patients12 (40%) underwent radiotherapy twice per day. Chi square test value is 1.286 ; p value- 0.994 (p>0.05). Majority of male patients 15 (50%) underwent 5 and above cycles of chemotherapy and both genders were equally distributed among 6(20%) undergoing 1-4 cycles of chemotherapy. Chi square test value is 1.377 ; p value is 0.994 (p>0.05).