Chronic kidney disease (CKD) is prone to progression, which can lead to more severe kidney disease and even death. The progression of CKD increases with age. CKD progression is higher in men due to hormonal aspects. Environment and genetics also affect the progression of CKD where the presence of APOL1 and uromodulin genes as well as an environment with HIV infection and heat due to occupational exposure can encourage the progression of CKD. Meanwhile, albuminuria and proteinuria, hypertension, heart failure, atrial fibrillation, sympathetic overactivity, fibroblast growth factor 23 (FGF23), serum bicarbonate, urinary oxalate, serum uric acid, parathyroid hormone levels, anemia, diabetes mellitus, metabolic acidosis, hyperuricemia, insulin resistance, dyslipidemia, obesity, smoking, a diet high in sodium, processed foods, and fat and other factors such as physical activity, pregnancy, acute kidney injury (AKI), renal fibrosis, gut-renal axis interactions and inflammatory conditions are modifiable factors related to CKD progression. Improving a healthy lifestyle with a healthy diet, not smoking, and physical activity as well as treating various pathological conditions such as hypertension, AKI, diabetes mellitus and others are efforts that can be useful to prevent CKD progression.