ISSN : 2663-2187

FORMULATION AND CHARACTERIZATION OF AZILSARTAN LOADED SELF EMULSIFYING DRUG DELIVERY SYSTEM

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Naina Dubey, Sampat Singh Tanwar, Seema Sharma, Shivam Soni, Mahima Dubey, Neelima Goswami, Basant Khare, Shubi Pathak, Sweta S Koka
» doi: doi.org/10.33472/AFJBS.6.9.2024.4816-4833

Abstract

The object of the present work was the advancement and portrayal of Azilsartan stacked self emulsifying drug conveyance framework is to increase its solubility and thereby dissolution rate and bioavailability. Self-Emulsifying Drug Delivery System was ready by the basic emulsification method. Six clumps for example F1 to F6 were ready by shifting the convergence of oils, surfactant, co-surfactant, and co-dissolvable and assessed for the different boundaries, for example, Optical microscopy, Assessment of self emulsification, Emulsification time, Droplet size investigation, Zeta Potential Measurement, Transmission Electron Microscopy, Viscosity Determination, Drug content, Percentage conveyance, in vitro disintegration study and solidness study. The SEDDS was upgraded and group F5 was additionally utilized. The medication content of chosen clump F5 was viewed as 97.65±1.37 %; it proposes that the technique for exemplification was powerful. As per in vitro study, around 55.13 % of the medication was delivered after 120 mins which showed supported

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