This study presents the successful development and characterisation of a nanogel formulation encapsulating curcumin and piperine for potential application in skin cancer therapy. The nanogel was prepared using the solvent evaporation method with carbopol polymer, and its physicochemical attributes were systematically investigated. Fourier-transform infrared spectroscopy (FT-IR) confirmed the encapsulation of curcumin and piperine within the carpool matrix, while scanning electron microscopy (SEM) and differential scanning calorimetry (DSC) elucidated the nano gel's morphology and thermal behaviour. Zeta potential and particle size analyses revealed a stable colloidal system with well-defined nanoscale characteristics. Drug release kinetics were also assessed, revealing a controlled and sustained release of curcumin and piperine from the nanogel over time. The anticancer activity of the nanogel was assessed using MTT assays on A231 skin cancer cells, demonstrating significant inhibition. The findings highlight the formulation's potential as an effective and targeted therapy for skin cancer.