The aim and objective of the present study was to formulate and evaluate Doxorubicin nanosponges for targeted delivery. Nanosponges were prepared using ethyl cellulose as the polymer and polyvinyl alcohol as the stabilizing agent by solvent evaporation method. The Nanosponges prepared were evaluated for different parameters like the drug: polymer ratio, stirring speed and time. The encapsulation and the diffusion study of the formulation were done. Particle size analysis and scanning electron microscopy of the nanosponges were performed and from this study it was found that the nanosponges were spherical in shape and have porous nature. The nanosponges prepared were incorporated into the gel base of carbapol. In diffusion study of the nanosponge gel was performed. Similarly, F6 and F7 exhibited the best release of 90.19% and 87.10% respectively at the end of 48 hours amoung all the five formulations of Doxorubicin – eudragit nanosponges