This study aimed to formulate a floating drug delivery system of Diltiazem hydrochloride and to evaluate the physicochemical characteristics, dissolution kinetics, and in vitro release profiles of floating tablets. The tablets were prepared using wet granulation method, and their physicochemical properties, including hardness, friability, and drug content, were determined. Dissolution kinetics were analysed using various mathematical models, and plasma drug concentration-time profiles were measured in a rat model. The floating tablets exhibited sustained release profiles with prolonged gastric retention times, while the immediate-release tablets showed faster release kinetics and shorter gastric retention times. Pharmacokinetic parameters such as Cmax, Tmax, and AUC were calculated to compare the drug exposure between the formulations. The results demonstrated that while the immediate-release tablets achieved higher peak plasma concentrations and total drug exposure, the floating tablets provided a more controlled and sustained release of the drug, potentially offering benefits for drugs requiring prolonged action and reduced dosing frequency.