ISSN : 2663-2187

“FORMULATION AND EVALUATION OF FLOATING TABLET OF RANITIDINE HCl”

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CHANCHAL CHOUDHARY , YOGENDRA MALVIYA , Dr. VIKAS JAIN
» doi: 10.48047/AFJBS.6.13.2024.6665-6688

Abstract

Tara gum, Hydroxypropyl methylcellulose K4M (HPMC K4M), carbopol 934, sodium bicarbonate, tartaric acid, and ranitidine HCL to create a new multiple-unit oral floating dosage form (I). To guarantee homogeneity and consistency, the formulation was extensively characterised using Fourier transform infrared spectroscopy (FTIR) and FTIR spectrophotometric analysis. The research verified that the drug content was more than 90%. We assessed the overall floating length and Floating Lag time for each of the eight formulations (F1– F8) and discovered that the medicine content was constant throughout the batches. With a greater concentration of Tara Gum and HPMC, batch F6's floating tablets stood out for their improved swelling index and longer floating duration. According to these findings, employing floating tablets for medicine administration improves therapeutic effectiveness and patient compliance. A floating drug delivery method that uses the right polymers to accomplish sustained and prolonged drug release is very promising.

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