The formulation and evaluation of Forskolin Phytosome, a novel herbal nanocomplex, have been investigated in this study. Forskolin, a natural diterpene extracted from the Indian Coleus plant (Coleus forskohlii), possesses remarkable therapeutic potential, particularly in enhancing cellular cyclic AMP levels. However, its clinical applications are hindered by poor solubility and low bioavailability. To overcome these limitations, Forskolin Phytosome was developed by complexing Forskolin with natural phospholipids. In this research, we present a comprehensive analysis of the formulation process, emphasizing the role of soy lecithin as a key component.