Aim: The main aim of present work is to develop herbal antifungal formulation by using latest technique and financially cheap and easily affordable for lay man as compare current dosage forms. Herbal granules preparation using lemon peel and neem leaves. Current study suggests that both drugs give antifungal effect. Objective Wet granulation techniques used to prepare herbal grannules which will be cheaper and less time consuming as compare to other dosage forms like tablet, capsules, syrups. The most common pathogen causing systemic fungal infection are candida albicans and aspergillus spp. Material and Methods: Lemon peel and neem leaves crushed and powdered. By using binder and distilled water and excipient made pest and dough was prepared and grannules were prepared by using wet granulation method. Result & Discussion: The final result is that both the API Citrus limon and Azadirachta Indica gives antifungal activity against bacteria which causes fungal infection. The final prepared gives antifungal activity. This preparation is not time consuming as compared to other dosage forms and also economical for commercialization on large scale basis. Conclusion: This research work focus on wet granulation technique is used, the process which is cheaper and less time consuming as compared to production of tablets, capsules and syrups. Hence, this formulation can serve as an ideal for commercialization on large scale and an inexpensive therapy as compared to currently available formulations in the market.