This paper describes the use of ultra-deformable nanovesicles for targeted delivery systems, which will increase the usage of nanovesicles in the present because of their exceptional capacity to penetrate the skin and increase the bioavailability of medications that are poorly soluble in water. The study includes a list of several vesicle kinds along with preparation and evaluation techniques. Transdermal Conveyance Framework (TDDS) has traditionally used ethersomes because they increase drug saturation via the skin. The planning of nanovesicles can be done using a variety of methods, including the hot, cold, transmembrane pH slope, ethanol infusion, and minimal film hydration strategies. By transdermal route, the UDV can be utilized to deliver many classes of pharmaceuticals, such as anti-toxin, anti-cancer, antiviral, anti-tumor, and pain-relieving drugs. This model incorporates a manufactured or homegrown pharmaceutical atom into vesicles that can penetrate the skin further for targeted drug delivery. And highly effective on subcutaneous layer.