Aspirin belongs to the nonsteroidal anti-inflammatory drug class used to reduce pain, fever, or inflammation. it additionally has an antiplatelet effect by inhibiting the COX1 activity in the platelet to prevent the manufacturing of thromboxane A2, which acts to bind platelets together throughout coagulation in addition to causing vasoconstriction and bronchoconstriction. Present work focuses only on the anti-platelet activity of Aspirin. The work aims to design, develop and evaluate an oral film containing Aspirin (using a dose of 37.5 mg) to increase the bioavailability of the drug and avoid extensive metabolism. Films were prepared by solvent casting method using excipients like film-forming agent (HPMC E5, HPMC E15, PVA, PVP K30), plasticizer (PEG 400, Glycerol, Propylene Glycol), Super disintegrant (Crospovidone, Croscarmellose and Sodium starch Glycolate) and sweetener (Aspartame). Formulated preliminary batches were subjected to characterisation such as the thickness of the film, folding endurance, and disintegration time. Sublingual films containing HPMC E15 LV Premium (film forming agent), PEG 400 (plasticizer) and CCS (Super disintegrant) show good results as that of marketed film formulation. Optimized batches were prepared among which batch B1, batch B3 and B5 showed desired drug release 95.93%, 89.151% and 90.21% respectively with 30, 32 and 37 seconds disintegration times.