Itopride hydrochloride (ITH) is a novel gastro-prokinetic agent that stimulates gastrointestinal motility through synergistic effects of D2 receptor blocker and acetyl choline esterase inhibitor. In the present work, Floating matrix tablets containing ITH were prepared by using various polymers and excipients designed to enhance the drug's gastroretentive properties. Hydrophilic polymer HPMC K100M with other release retarding and matrix forming polymers (Eudragit RSPO 100, sodium alginate, ethyl cellulose, psyllium husk, xanthan gum and carbapol 971P) using polyvinyl pyrolidine K30 ( dry binder) and gas forming agent sodium bicarbonate. FTIR study conducted to confirm compatibility between ITH and the excipients. No significant interactions were found, indicating the excipients are suitable for the formulation. All tablet formulations showed acceptable physical properties but, the formulation composition (F-3) containing HPMC K100 M and ethyl cellulose showed excellent floating behaviour and sustained drug release characteristics. F-3 formulation showed minimum floating lag time (0.2944 minutes) remained floated for 24 hours and cumulative % drug release 99.67%. Drug release from F-3 floating matrix tablet followed Higuchi kinetic model with R2 value 0.9926.