Antihistamines play a crucial role in managing allergic conditions, and the newer, less sedating antihistamines are preferred due to their good safety profile and long-term efficacy. Fexofenadine HCl is a second-generation antihistamine primarily used to treat allergic rhinitis and chronic urticaria. Despite its efficacy, conventional dosage forms, such as tablets and syrups, pose challenges, particularly for paediatric and geriatric patients who may experience difficulty swallowing solid dosage forms. To address these limitations, orodispersible films (ODFs) have emerged as promising alternative dosage forms because of their ability to disintegrate rapidly upon contact with saliva, thus offering ease of administration without the need for water. Materials and Methods: During pre-formulation studies, the drug excipient compatibility, flow properties, and disintegration time were thoroughly analyzed. Out of the polymers used, HPMC and HPC proved to be the most effective in creating the film. Results and Discussion: The drug maintained its initial crystallinity and physical and chemical properties in the formulated ODF. By adding a surfactant and plasticizer, the tensile strength of the oral strip increased. Conclusion: The solvent casting method was employed to fabricate the ODF using different polymers. HPMC and HPC were found to be optimal for film formation. The fexofenadine HCl drug retained its initial properties in the formulated ODF. Surfactant and plasticizer additives enhanced the film's tensile strength, ensuring stability and ease of distribution. The ODF exhibited excellent thickness, contributing to taste masking.