This study focuses on the formulation and evaluation of a polyherbal antifungal cream, designed to combat common dermatophyte infections. Utilizing a combination of traditional medicinal plants known for their antifungal properties, such as Neem (Azadirachta indica), garlic (allium sativum) turmeric (curcumalonga), etc we aimed to develop a safe, effective, and bioavailable topical treatment. The cream was formulated using a standardized extraction method to ensure consistency in active ingredient concentration. Physicochemical evaluations, including pH, viscosity, and spreadability, were conducted to assess the cream's stability and applicability. Antifungal efficacy was tested against common pathogens, including Candida albicans and Trichophyton rubrum, using in vitro methods. The results demonstrated significant antifungal activity, with minimal skin irritation observed during patch testing on human volunteers. Overall, this polyherbal cream shows promising potential as a natural alternative to conventional antifungal therapies, emphasizing the role of herbal formulations in contemporary medicine. Further clinical trials are recommended to establish long-term efficacy and safety profiles.