Topical drug delivery allows for localized treatment through various routes such as ophthalmic, rectal, vaginal, and cutaneous. For skin diseases caused by fungi, antifungal agents like Posaconazole are utilized. This study aimed to develop and evaluate Posaconazole-loaded Invasomal gels, enhancing topical drug delivery. Invasomes were created using a mechanical dispersion method with phosphatidylcholine, terpenes, and ethanol. Formulations (F1-F6) were assessed for appearance, pH, vesicle size, drug content, entrapment efficiency, zeta potential, and in-vitro drug diffusion. The vesicle size ranged from 206 to 262 µm, with drug content between 74.40% and 81.35%. The entrapment efficiency varied from 52.56% to 82.49%, with formulation F5 showing the highest drug diffusion of 92.78% after 8 hours. The optimized Invasomal gel (IG-2) showed favorable properties including a pH of 5.2, viscosity of 3156 cps, and drug diffusion of 91.77%. Stability studies confirmed IG-2's stability over time. This study demonstrates that Invasomal gels can significantly enhance the bioavailability of topical antifungal treatments.