The study aimed to develop and evaluate a pulsatile drug delivery system (PDDS) for Hydrochlorothiazide, a thiazide diuretic commonly used for managing hypertension and edema. The PDDS was designed to synchronize drug release with the body's circadian rhythm, targeting early morning peaks in blood pressure. Using the wet granulation method, core tablets were formulated using various super disintegrants (Lycoat, Sodium starch glycolate, and Ludiflash). These tablets were then coated with natural and synthetic polymers, including Xanthan gum, Karaya gum, HPMC K4M, and HPMC K15M, to control the release profile. The formulations were evaluated for pre- and postcompression parameters, drug content uniformity, in vitro drug release, and dissolution kinetics. The optimized core tablet formulation (F9) and coated tablet formulation (C7F9) were identified based on their ability to maintain a lag phase followed by a burst release at the desired time, which was confirmed by release kinetics analysis indicating a first-order release mechanism and super case II transport. The study concludes that the PDDS developed for Hydrochlorothiazide can effectively provide a time-dependent release profile, making it suitable for chronotherapy in hypertension management.